|
KMID : 0869120010030010063
|
|
기초간호자연과학회지
2001 Volume.3 No. 1 p.63 ~ p.74
|
|
|
Effect of DHEA administration during dexamethasone treatment of mass of hindlimb muscles of rat
|
|
Shin Gi-Soo
|
|
|
Abstract
|
|
|
The purpose of this study was to determine the effect of DHEA with dexamethasone on body weight and wet weight and relative weight of atrophied hindlimb muscles induced by dexamethasone treatment. 200∼225g Wistar rats were divided into
control(C),
dexamethasone(D), dexamethasone and DHEA(DDH) groups. Dexamethasone was injected daily at a dose of 5㎎/㎏. DHEA was administered daily at a dose of 5㎎/㎏ by oral ingestion during 7days. The data were analyzed by Kruskal-Wallis test and
Mann-Whiteny U
test using the SPSSWIN 9.0 program. Body weight and muscle weight of plantaris and gastrocnemius of dexamethasone group decreased significantly compared with that of control group. Muscle weight of plantaris of DDH group increased significantly
compared
with dexamethasone group. Body weight of DDH group decreased significantly compared to control group, but relative weight of plantaris and gastrocnemius of DDH group increased significantly compared to control group. Based on these results, it
can
be
suggested that DHEA administration during dexamethasone treatment can be suggested that DHEA administration during dexamethasone treatment can increase weight of atrophied plantaris muscle induced by dexamethasone treatment.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|